Aging Augments IL-17 T-Cell Alloimmune Responses

Elevated IL-17 and TGF-β Serum Levels: A Positive Correlation between T-helper 17 Cell-Related Pro-Inflammatory Responses with Major Depressive Disorder

Introduction: Depression is a mental disorder that highly associated with immune system. Therefore, this study compares the serum concentrations of IL-21, IL-17, and transforming growth factor β (TGF-β) between patients with major depressive disorder and healthy controls. Methods: Blood samples were collected from 41 patients with major depressive disorder and 40 healt...

The IL-33/ST2 axis augments effector T-cell responses during acute GVHD.

Interleukin (IL)-33 binding to the receptor suppression of tumorigenicity 2 (ST2) produces pro-inflammatory and anti-inflammatory effects. Increased levels of soluble ST2 (sST2) are a biomarker for steroid-refractory graft-versus-host disease (GVHD) and mortality. However, whether sST2 has a role as an immune modulator or only as a biomarker during GVHD was unclear. We show increased IL-33 prod...

Restricted T Cell Responses to − HLA - A * 0201 Deficiency Augments

Altered IL-7Ralpha expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses.

We investigated the effects of aging on the IL-7-mediated CD8+ T-cell survival pathway and of IL-7 therapy on T-cell immunity. Cells expressing IL-7 receptor (IL-7R) alphahigh and alphalow were identified in a CD45RA+ effector memory (EM(CD45RA+), CD45RA+CCR7-) CD8+ T-cell subset. Elderly subjects (65 years and older) had an increased frequency of EM(CD45RA+) IL-7Ralphalow) CD8+ T cells, leadin...

Altered IL-7R expression with aging and the potential implications of IL-7 therapy on CD8 T-cell immune responses

We investigated the effects of aging on the IL-7–mediated CD8 T-cell survival pathway and of IL-7 therapy on T-cell immunity. Cells expressing IL-7 receptor (IL-7R) high and low were identified in a CD45RA effector memory (EMCD45RA , CD45RA CCR7 ) CD8 T-cell subset. Elderly subjects (65 years and older) had an increased frequency of EMCD45RA IL7R low CD8 T cells, leading to decreased STAT5 phos...